Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

16.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
16.0K
Bone Remodeling01:40

Bone Remodeling

40.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unveiling Chouguiyu: A Review of Flavor Development, Microbial Dynamics, and Texture Formation in Fermented Mandarin Fish.

Journal of food science·2026
Same author

PIN1 inhibits ferroptosis in gastric cancer cells by regulating the CPEB1‑GPX4 pathway.

Oncology reports·2026
Same author

Disrupting SOX2 self-association and condensate formation to overcome chemotherapeutic drug resistance in lung squamous cell carcinoma.

Signal transduction and targeted therapy·2026
Same author

Case Report: Juvenile dermatomyositis complicated by acute myeloid leukemia: achievement of sustained remission through hematopoietic stem cell transplantation.

Frontiers in immunology·2026
Same author

Co-morbid biomarkers for sarcopenic obesity associated with gut microbiota metabolites: From burden to treatment.

PLoS computational biology·2026
Same author

External validation of three risk prediction models for deep vein thrombosis in patients with acute stroke: a single-center cohort study.

Frontiers in cardiovascular medicine·2026

Related Experiment Video

Updated: Jan 18, 2026

A Mouse Distraction Osteogenesis Model
04:24

A Mouse Distraction Osteogenesis Model

Published on: November 14, 2018

6.7K

Progress in immunoregulatory mechanisms during distraction osteogenesis.

Shiyu Huang1,2, Aoran Zeng1, Qing Yin2

  • 1Department of Orthopaedic and Reconstructive Surgery/Pediatric Orthopaedics, South China Hospital, Medical School, Shenzhen University, Shenzhen, China.

Frontiers in Bioengineering and Biotechnology
|September 10, 2025
PubMed
Summary

Distraction osteogenesis (DO) harnesses bone regeneration through distinct phases. This review explores the immune system

Keywords:
biomaterialsbone regenerationcytokinesdistraction osteogenesisimmunomodulation

More Related Videos

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
09:26

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur

Published on: October 23, 2017

7.9K
Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential
05:25

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Published on: July 21, 2023

1.9K

Related Experiment Videos

Last Updated: Jan 18, 2026

A Mouse Distraction Osteogenesis Model
04:24

A Mouse Distraction Osteogenesis Model

Published on: November 14, 2018

6.7K
An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
09:26

An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur

Published on: October 23, 2017

7.9K
Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential
05:25

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Published on: July 21, 2023

1.9K

Area of Science:

  • Orthopedics and Regenerative Medicine
  • Immunology
  • Biomaterials Science

Background:

  • Distraction osteogenesis (DO) is a key bone regeneration technique used in reconstructive surgery.
  • DO involves latency, distraction, and consolidation phases, each with unique biological events.
  • The immune system's role in DO is increasingly recognized as crucial for successful outcomes.

Purpose of the Study:

  • To review the temporal immune responses during distraction osteogenesis.
  • To elucidate the functions and regulatory mechanisms of immune cells in DO.
  • To explore the potential of immunomodulatory biomaterials in enhancing DO therapies.

Main Methods:

  • Literature review focusing on immune cell dynamics during DO phases.
  • Analysis of current research on immunomodulatory strategies in DO.
  • Exploration of bioactive materials influencing immune responses in bone regeneration.

Main Results:

  • Immune cell populations and functions change dynamically throughout the DO process.
  • Specific immune cells and their mediators play critical roles in each DO phase.
  • Immunomodulatory interventions show promise for optimizing DO outcomes.

Conclusions:

  • Understanding the temporal immune regulation in DO is vital for therapeutic advancements.
  • Targeting immune responses offers novel strategies to improve distraction osteogenesis.
  • Immunomodulatory biomaterials represent a promising avenue for enhancing bone regeneration in DO.