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Updated: Jan 18, 2026
![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Decarboxylative Pyrazolylation of Aryl Carboxylic Acids via Synergetic Organic-Photoredox and Copper Catalysis
Wen-Wen Li1, Decai Ding1, Yang Li1
1Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 712046, P. R. China.
Abstract:
The decarboxylative amination of aryl carboxylic acids with low toxicity, structural diversity, and ready availability remains relatively underexplored. Current protocols typically require the use of overstoichiometric metal additives and/or strong oxidants as well as high reaction temperatures. Herein we report decarboxylative amination of aryl carboxylic acids with pyrazoles via synergistic organic-photoredox and copper catalysis under mild conditions, employing air as a green oxidant. The limitations of the current protocols are effectively addressed.
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