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Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas
Published on: September 5, 2011
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Calcification density in single and twin placenta villi
Maggie Guess1, Sheila Criswell1
1Department of Diagnostic and Health Sciences, University of Tennessee Health Science Center, Memphis, TN, USA.
Journal of Histotechnology
|September 10, 2025
Summary
Placental calcifications, common in third-trimester pregnancies, do not differ between singleton and twin placentas. This suggests calcifications are a normal maturational process, not a sign of fetal distress.
Area of Science:
- Obstetrics and Gynecology
- Developmental Biology
- Pathology
Background:
- Placental calcifications are common in aging placentas and have been linked to fetal distress.
- Understanding calcification in different pregnancy types is crucial for accurate interpretation.
Purpose of the Study:
- To compare calcification densities in singleton, fused twin, and non-fused twin placentas.
- To determine if placental calcifications indicate fetal distress or normal maturation.
Main Methods:
- Analysis of 139 placental tissues (singleton, fused twin, non-fused twin) from the third trimester.
- Quantification of calcification density using the von Kossa stain for calcium salts.
Main Results:
- No significant differences in calcification densities were found among the different placental types.
- Nearly all third-trimester placentas examined exhibited calcifications.
Conclusions:
- Placental calcifications in the third trimester appear to be a normal maturational process.
- Twin pregnancies do not show increased placental stress due to calcifications.
- Findings may reassure patients and providers managing twin pregnancies.
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