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Updated: Jan 18, 2026

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CHDH Promotes Breast Cancer Metastasis Relying on IL17RB/CREB1 Signalling Activation.

Yifei Li1,2,3, Yipeng Liu1, Xiaowen Yang1

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Journal of Cellular and Molecular Medicine
|September 10, 2025
PubMed
Summary

Choline Dehydrogenase (CHDH) promotes breast cancer metastasis by influencing IL17RB and activating CREB. Targeting CHDH may offer new therapeutic strategies for metastatic breast cancer.

Keywords:
CHDHIL17RB/CREBbreast cancer (BC)metastasismigration

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Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Choline Dehydrogenase (CHDH) is implicated in metabolic disorders and tumor progression.
  • Its specific role in breast cancer (BC) metastasis requires further investigation.

Purpose of the Study:

  • To investigate the role of CHDH in breast cancer metastasis.
  • To elucidate the underlying molecular mechanisms of CHDH-mediated metastasis.

Main Methods:

  • Analysis of CHDH protein expression in breast cancer tissues and cell lines.
  • CHDH gene silencing and overexpression experiments in vitro and in vivo.
  • Investigation of downstream targets including IL17RB and CREB signaling.

Main Results:

  • CHDH expression is significantly elevated in breast cancer tissues and cell lines, correlating with TNM stage.
  • CHDH silencing reduced breast cancer cell migration; overexpression increased migration and metastasis.
  • CHDH influences IL17RB expression and activates CREB, mediating metastasis.
  • IL17RB antibody and CREB inhibitor abrogated CHDH-mediated cell migration.

Conclusions:

  • CHDH is a critical promoter of breast cancer metastasis.
  • CHDH-IL17RB-CREB signaling pathway is a key mechanism driving metastasis.
  • CHDH presents a potential therapeutic target for metastatic breast cancer.