Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cochlear function and audiogenic seizures: developmental covariance in the LP/J mouse.

K R Henry

    Developmental Psychobiology
    |November 1, 1985
    PubMed
    Summary

    Audiogenic seizure susceptibility in mice is linked to cochlear function. High-frequency hearing loss correlates strongly with sound-induced seizures, suggesting a mechanism for susceptibility.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cochlear nerve acoustic envelope response detection is improved by the addition of random-phased tonal stimuli.

    Hearing research·2001
    Same author

    Essential roles of noise in neural coding and in studies of neural coding.

    Bio Systems·2001
    Same author

    Low-frequency acoustic modulations generated by the high-frequency portion of the cochlea, noninvasively recorded from the scalp of mice (Mus musculus).

    Journal of comparative psychology (Washington, D.C. : 1983)·2000
    Same author

    Temporal factors associated with cochlear nerve tuning to dual and single tones: a qualitative study.

    The Journal of the Acoustical Society of America·1999
    Same author

    Killer whale (Orcinus orca) hearing: auditory brainstem response and behavioral audiograms.

    The Journal of the Acoustical Society of America·1999
    Same author

    Noise improves transfer of near-threshold, phase-locked activity of the cochlear nerve: evidence for stochastic resonance?

    Journal of comparative physiology. A, Sensory, neural, and behavioral physiology·1999

    Area of Science:

    • Neuroscience
    • Auditory Neuroscience
    • Genetics

    Background:

    • Innate susceptibility to audiogenic seizures varies with genotype and environment.
    • Auditory dysfunction can experimentally induce seizure susceptibility.

    Purpose of the Study:

    • To correlate cochlear function with audiogenic seizure susceptibility in LP/J mice.
    • To investigate the relationship between hearing thresholds and seizure onset/severity.

    Main Methods:

    • LP/J mice were tested for seizure susceptibility and cochlear nerve-evoked potential thresholds.
    • Measurements were taken across a developmental age range (8-120 days).

    Main Results:

    • Seizure susceptibility emerged at 12 days, peaked at 18-32 days, and declined by 120 days.
    • Cochlear thresholds were highest at 12 days, lowest at 18-32 days, and increased thereafter.
    • Strong negative correlation (r = -0.93) found between high-frequency hearing loss and seizure susceptibility.

    Conclusions:

    • Intermediate high-frequency cochlear damage, from genetic or environmental factors, likely causes audiogenic seizure susceptibility.
    • Cochlear function, particularly high-frequency hearing, is a critical factor in audiogenic seizures.

    Related Experiment Videos