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Updated: Jan 18, 2026

Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface
Published on: July 4, 2018
Exploring tumour-microbe interactions: in vitro and in vivo modelling of Streptococcus bovis-induced colorectal
Khairiyah Murad1, Hassanain Al-Talib2
1Institute for Medical and Molecular Biotechnology (IMMB), Faculty of Medicine, Selangor Branch, Universiti Teknologi MARA (UiTM) Sungai Buloh Campus, Jalan Hospital, Sungai Buloh, 47000, Selangor, Malaysia.
Abstract:
Streptococcus bovis is an opportunistic bacterium consistently associated with colorectal cancer (CRC). This article reviews previous experimental evidence that has successfully demonstrated the role of S. bovis species in the context of CRC. The emerging evidence from experimental studies shows that the development of CRC involves synergistic mechanisms. This includes microbial dysbiosis or bacterial factors, evasion of the host immune system leading to chronic inflammatory responses, and alterations in cellular signalling pathways, which together promote tumour development and progression. The review may contribute to a better understanding of the role of S. bovis in CRC and its potential as a microbial biomarker and cancer therapeutic target.
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