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Author Spotlight: Understanding Cytokine-Induced Cell Death in Intestinal Epithelial Cells Using Human Organoids
Published on: August 2, 2024
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Lysosome-dependent cell death: disease implications and potential therapeutic targets
Ahequeli Gemingnuer1, Rui Yin1, Yan Liu1
1School of Pharmacy, Heilongjiang University of Chinese Medicine, NO 24 Heping Road, 150040, Harbin, P. R. China.
Molecular Biology Reports
|September 10, 2025
Summary
Lysosome-dependent cell death (LDCD) involves lysosomal enzyme release causing cell damage. Understanding LDCD mechanisms offers new therapeutic targets for diseases linked to lysosomal dysfunction.
Area of Science:
- Cell Biology
- Pathology
- Pharmacology
Background:
- Lysosome-dependent cell death (LDCD) is a regulated cell death pathway.
- It involves lysosomal membrane permeabilization and enzyme release, causing cellular damage.
- LDCD is implicated in neurodegenerative diseases, cancer, cardiovascular, and autoimmune disorders.
Purpose of the Study:
- To provide a comprehensive review of lysosome-dependent cell death.
- To explore LDCD's molecular pathways, role in disease, biomarkers, and therapeutic targets.
- To bridge the gap in recent reviews on LDCD therapeutic strategies.
Main Methods:
- Systematic review of molecular pathways in LDCD.
- Analysis of LDCD's role in various pathological conditions.
- Identification and discussion of potential clinical biomarkers and therapeutic interventions.
Main Results:
- Detailed elucidation of molecular mechanisms controlling lysosomal membrane instability and enzyme release.
- Comprehensive overview of LDCD's involvement in diverse diseases.
- Identification of potential therapeutic targets and biomarkers for LDCD-related conditions.
Conclusions:
- A deeper understanding of LDCD mechanisms is crucial for disease management.
- Targeting LDCD pathways presents promising therapeutic opportunities.
- This review provides a foundation for future research and drug discovery in LDCD.
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