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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
909
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
604
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

843
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
843
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

328
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
328
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

721
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
721

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Updated: Jan 6, 2026

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
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From Gut Inflammation to Cardiovascular Conflagration: Mapping IBD's Cardiometabolic Risks.

Oscar Noble1,2, Dayoung Jeon1, Megan Lewis1

  • 1Division of Gastroenterology and Hepatology, Lynda K. and David M. Underwood Center for Digestive Health, Houston Methodist Hospital, Houston, TX, USA.

Current Atherosclerosis Reports
|September 10, 2025
PubMed
Summary
This summary is machine-generated.

Inflammatory bowel disease (IBD) is linked to increased cardiovascular disease (CVD) risk due to gut dysbiosis and inflammation. Managing IBD activity and risk factors is crucial for preventing heart complications in patients.

Keywords:
Cardiovascular diseaseInflammationInflammatory bowel diseaseMicrobiome

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Area of Science:

  • Gastroenterology and Cardiology
  • Immunology and Inflammation

Background:

  • Inflammatory bowel disease (IBD) is associated with significant, often underrecognized, cardiovascular complications.
  • Patients with IBD face increased risks of coronary artery disease (CAD), arrhythmias, heart failure, and venous thromboembolism, often without traditional risk factors.

Purpose of the Study:

  • To characterize cardiovascular manifestations in inflammatory bowel disease (IBD).
  • To elucidate the mechanisms underlying the association between IBD and cardiovascular disease (CVD).

Main Methods:

  • Literature review of existing studies on IBD and cardiovascular health.
  • Analysis of mechanisms including gut dysbiosis, systemic inflammation, and non-traditional risk factors.

Main Results:

  • Gut dysbiosis, inflammation, micronutrient deficiencies, anemia, and sarcopenia contribute to elevated CVD risk in IBD patients.
  • IBD patients experience earlier onset and higher incidence of CVD, including CAD, arrhythmias, and heart failure.
  • Disease activity, duration, and IBD medications are significant non-traditional risk factors for CVD.

Conclusions:

  • Minimizing IBD activity, optimizing nutrition, and addressing gut dysbiosis can reduce CVD burden.
  • Close monitoring of cardiovascular health and risk factors is essential for IBD patients, especially during disease flares.