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Updated: Jan 18, 2026

Author Spotlight: Accelerating Discovery in Microporous Material Chemistry
Published on: October 6, 2023
Morpholino-based phosphorothioate analogs via oxathiaphospholane chemistry: synthesis, structural insights and
Katarzyna Jastrzębska1, Agata Szymańska1, Tomasz Pawlak1
1Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Department of Bioorganic Chemistry, Sienkiewicza 112, 90-363 Łódź, Poland. katarzyna.jastrzebska@cbmm.lodz.pl.
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We present the application of the oxathiaphospholane method for the synthesis of novel P-stereodefined phosphorothioate N-modified morpholino analogs, showcasing its potential for creating therapeutically relevant compounds. Additionally, we provide valuable structural insights into their stereochemistry, including a detailed analysis of stereochemical configurations. We also report on the enzymatic stability of these compounds in 10% (v/v) fetal bovine serum (FBS), thereby mimicking in vivo conditions. These findings pave the way for further exploration of P-stereodefined nucleic acid analogs in molecular medicine and gene therapy applications.
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