Expression and Genetic Polymorphisms of CXCR5 Are Associated with Postoperative Incisional Pain in Patients Undergoing Laparoscopic Cholecystectomy
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View abstract on PubMed
Summary
This summary is machine-generated.CXCR5 expression and its rs3922 genetic variant are linked to postoperative incisional pain in acute cholecystitis patients undergoing laparoscopic cholecystectomy. These findings suggest CXCR5 as a potential biomarker for predicting and managing pain.
Area Of Science
- Molecular Biology
- Surgical Oncology
- Pain Management
Background
- Postoperative incisional pain is a significant concern for patients undergoing laparoscopic cholecystectomy for acute cholecystitis.
- Identifying reliable biomarkers for pain severity is crucial for effective pain management strategies.
Purpose Of The Study
- To identify biomarkers associated with postoperative incisional pain in patients with acute cholecystitis after laparoscopic cholecystectomy (ACC-LC).
- To investigate the role of CXCR5 expression and its single nucleotide polymorphism (rs3922) in pain severity and related inflammatory markers.
Main Methods
- RNA sequencing was employed to screen potential pain-associated markers in 60 ACC-LC patients.
- ELISA quantified CXCR5 expression in peripheral blood mononuclear cells (PBMCs).
- Single nucleotide polymorphism (SNP) genotyping for CXCR5 rs3922 was performed, correlating with pain, inflammation, and clinical features.
Main Results
- CXCR5 expression was significantly higher in patients with moderate-to-severe pain (MSP) compared to mild pain (MP) groups, correlating with visual analog scale (VAS) scores.
- The CXCR5 rs3922 G allele was linked to increased pain, elevated Interleukin-6 (IL-6), and decreased Transforming Growth Factor-beta (TGF-β) levels.
- GG genotype carriers showed higher liver enzymes (AST, ALT), indicating liver damage, and experienced longer recovery times and more complications.
Conclusions
- CXCR5 expression and the rs3922 polymorphism are associated with incisional pain and inflammatory damage in ACC-LC patients.
- CXCR5 emerges as a potential predictive biomarker for postoperative pain severity.
- These findings support the development of personalized pain management strategies targeting CXCR5.
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