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Updated: May 4, 2026

Direct Force Measurements of Subcellular Mechanics in Confinement using Optical Tweezers
Published on: August 31, 2021
End-to-end inverse design for programmable acoustic tweezers with simultaneous force and torque control by
Yu Liu1, Hao-Wen Dong2, Xue Jiang3
1Department of Mechanics, School of Mechanical Engineering, Tianjin University, Tianjin 300350, China.
Abstract:
Acoustic tweezers leverage acoustic radiation forces for noncontact manipulation. One of the core bottlenecks in multidimensional manipulation is the lack of a systematic design methodology, which prevents the generation of an acoustic field that simultaneously meets the collaborative control requirements of multi-degree-of-freedom forces and torques, making it difficult to achieve precise control under conditions of stable suspension, high-frequency rotation, and complex spatial constraints. To address this challenge, we develop an end-to-end inverse design methodology for acoustic tweezers based on coding metasurfaces, establishing a dual-objective, dual-scale optimization paradigm. At the microscale, the phase modulation and transmission efficiency are co-optimized through coupled physical models. While at the mesoscale, the particle suspension and rotation dynamics are considered. Based on the inverse design framework constructed with a finite-bit element library, we successfully optimized the metasurface configuration with specific acoustic response characteristics and achieved noncontact, multi-degree-of-freedom customized manipulation of individual particles. This approach provides implementation pathways for adaptive multiscale strategies in precision engineering applications.
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