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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.7K

Clinical and Laboratory Predictors for the Development of Heart Valve Diseases in Chronic Kidney Disease: A

Hayala Machado Cavalcante Conceição1, Ana Luísa Vaz Valois1, Erick Magalhães Silva Ramos2

  • 1Escola Bahiana de Medicina e Saúde Pública, Salvador, BA - Brasil.

Arquivos Brasileiros De Cardiologia
|September 10, 2025
PubMed

Insights

In chronic kidney disease (CKD) patients, factors like age, renal replacement therapy, and inflammation significantly increase cardiac valve calcification (CVC) risk. Monitoring these can aid in prevention and treatment strategies.

Area of Science:

  • Nephrology
  • Cardiology
  • Biochemistry

Background:

  • Chronic kidney disease (CKD) is linked to increased valvular diseases and cardiovascular mortality.
  • The specific factors driving cardiac valve calcification (CVC) in CKD patients remain unclear.

Purpose of the Study:

  • To identify risk factors for valvular calcification in patients with chronic kidney disease.

Main Methods:

  • A systematic review following PRISMA guidelines analyzed observational studies.
  • Included studies assessed clinical and laboratory data associated with CVC in CKD patients undergoing dialysis.
  • Methodological quality and risk of bias were evaluated using STROBE and Newcastle-Ottawa guidelines.

Main Results:

  • Twenty studies involving 13,314 CKD patients were included.
  • Key risk factors for CVC included older age (>55 years), reduced glomerular filtration rate (<53 mL/min/1.73m2), and prolonged renal replacement therapy (RRT >20 months).
  • Other significant factors were hypoalbuminemia, elevated C-reactive protein (CRP), IL-6, TNF-α, parathyroid hormone, hyperphosphatemia, hypercalcemia, Ca × P product, and FGF-23, all linked to secondary hyperparathyroidism.

Conclusions:

  • Age, RRT duration, chronic inflammation, and secondary hyperparathyroidism are pivotal in promoting calcium and phosphate deposition in heart valves of CKD patients.
  • These factors increase susceptibility to CVC, highlighting potential targets for prevention and treatment.
Abstract

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