The PROtective VEntilation (PROVE) Network - advancing research and collaboration in mechanical ventilation

Area of Science:

• Critical Care Medicine
• Respiratory Medicine
• Clinical Research Networks

Background:

• The PROtective Ventilation (PROVE) Network addresses critical questions in intraoperative and intensive care mechanical ventilation.
• It focuses on improving patient outcomes across various settings, including operating rooms, ICUs, burn units, and resource-limited areas.

Purpose of the Study:

• To review the history, key projects, and leadership of the PROVE Network.
• To highlight the network's contributions to advancing research, education, and collaboration in mechanical ventilation.

Main Methods:

• The PROVE Network conducts a comprehensive portfolio of investigations, including randomized clinical trials, observational research, and meta-analyses.
• It emphasizes mentorship, collaboration, gender balance, and diversity to foster innovation and research excellence.

Main Results:

• The network's work has significantly contributed to understanding optimal ventilation strategies for critically ill patients, including those with COVID-19.
• Pioneering studies have shaped global clinical practice, exploring innovative approaches like closed-loop ventilation systems, personalized ventilation, and Artificial Intelligence.

Conclusions:

• The PROVE Network exemplifies the power of global collaboration in addressing complex clinical challenges in mechanical ventilation.
• Its initiatives drive meaningful innovation and improve patient care worldwide through evidence-based strategies and knowledge transfer.