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The staging evolution dilemma: TNM-9 sharpens anatomical precision, but is biology still offstage?

Gustavo Faibischew Prado1,2,3, Fernanda Kaori Fujiki3,4, João Marcelo Lopes Toscano de Brito3

  • 1. Comitê Científico de Câncer de Pulmão, Sociedade Brasileira de Pneumologia e Tisiologia, Brasília (DF), Brasil.

Jornal Brasileiro De Pneumologia : Publicacao Oficial Da Sociedade Brasileira De Pneumologia E Tisilogia
|September 10, 2025
PubMed
Abstract

No abstract available in PubMed .

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Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...