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Updated: Jan 18, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Recent Advances in the Isolation, Bioactivity, Biosynthesis, and Total Synthesis of Hamigerans
Xia Zhou1, Jian-Hua Xie2, Yao Jian1
1Green Pharmaceutical Technology Key Laboratory of Luzhou City, School of Pharmacy, Southwest Medical University, Luzhou 646000, P. R. China.
Abstract:
Hamigerans, a class of diterpenoid natural products isolated from marine sponge Hamigera tarangaensis, are characterized by distinctive 6-6-5 or 6-7-5 tricyclic skeletons. These compounds have been a focal point for synthetic chemists in recent years due to their remarkable biological activities. In this Review, we summarize the progress made in the isolation, biosynthesis, bioactivity, and total synthesis of hamigerans, with particular emphasis on synthetic studies published since 2013. Our goal for this Review is to provide new insights for future research on this class of marine natural products.
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