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Topical Capsaicin as a Preventative Treatment for Chemotherapy-Induced Peripheral Neuropathy (CIPN): A Case Series
1The University of Texas MD Anderson Cancer Center, Houston, TX.
Background:
Chemotherapy-induced peripheral neuropathy (CIPN) is a well-known adverse effect of chemotherapy treatment. Despite its prevalence, prevention and treatment of CIPN remain challenging.
Case Report:
In this case series, we present the use of topical 0.075% capsaicin as a preventative measure for CIPN in patients with newly-diagnosed stage II breast cancer undergoing chemotherapy. Patients were instructed to use capsaicin cream 3 times daily on hands and feet throughout the course of chemotherapy and for an additional month after chemotherapy concluded.
Conclusions:
None of the 5 patients had any symptoms suggestive of CIPN after being followed for 12 months. These findings support further investigation of low-dose capsaicin as a prophylactic measure to prevent CIPN.
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