Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

427
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
427

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cerebrospinal fluid transcriptional immune pathways linked to survival in HIV-associated tuberculous meningitis.

The Journal of infectious diseases·2026
Same author

Fibroblastic aspartoacylase suppresses TGFβ-mediated responses and cancer progression.

Nature communications·2026
Same author

Incidence and strategies for prevention of adjustable loop suspensory fixation maldeployment in multiligament knee reconstruction.

Journal of ISAKOS : joint disorders & orthopaedic sports medicine·2026
Same author

Probiotic-Induced Gut Microbiota Modulation: A Comparative Analysis Using 16S rRNA V3-V4 and Targeted Sequencing.

Microorganisms·2026
Same author

Enhanced label-free SERS detection of uremic toxins in clinical spent dialysate.

Analytica chimica acta·2026
Same author

AEGIS reveals epitope- and clone-resolved convergence of CNS B and T cell autoreactivity in ROHHAD.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Jan 18, 2026

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis
09:01

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis

Published on: November 17, 2020

7.7K

Complement Factor I Deficiency With Acute Hemorrhagic Leukoencephalitis and Longitudinally Extensive Transverse

Tiffany Hu1, Javier Rodriguez2, Lara L Zimmermann1,3

  • 1Department of Neurology, UC Davis Medical Center, Sacramento, CA.

Neurology(R) Neuroimmunology & Neuroinflammation
|September 10, 2025
PubMed
Summary

Complement factor I (CFI) deficiency can cause severe CNS autoinflammation. Genetic testing identified partial CFI deficiency, and IL-1 receptor antagonism successfully treated the condition.

More Related Videos

Isolation of Brain-infiltrating Leukocytes
06:44

Isolation of Brain-infiltrating Leukocytes

Published on: June 13, 2011

19.8K
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

7.0K

Related Experiment Videos

Last Updated: Jan 18, 2026

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis
09:01

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis

Published on: November 17, 2020

7.7K
Isolation of Brain-infiltrating Leukocytes
06:44

Isolation of Brain-infiltrating Leukocytes

Published on: June 13, 2011

19.8K
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

7.0K

Area of Science:

  • Neuroimmunology
  • Complement System Biology
  • Rare Genetic Disorders

Background:

  • Complement factor I (CFI) deficiency is a rare genetic disorder.
  • It can manifest as severe, relapsing central nervous system (CNS) autoinflammation.
  • Unexplained neuroinflammation poses diagnostic challenges.

Purpose of the Study:

  • To report a case of partial CFI deficiency presenting with fulminant CNS autoinflammation.
  • To highlight the diagnostic utility of genetic testing in unexplained neuroinflammatory conditions.
  • To evaluate the efficacy of IL-1 receptor antagonism in this context.

Main Methods:

  • Case report of a young adult with acute hemorrhagic leukoencephalitis and transverse myelitis.
  • In-hospital whole-genome sequencing and complement testing.
  • Cerebrospinal fluid (CSF) profiling, including cytokine and gene expression analysis.
  • Treatment with IL-1 receptor antagonist (anakinra).

Main Results:

  • Partial CFI deficiency was diagnosed via genetic and complement testing.
  • CSF analysis revealed neutrophil and pro-inflammatory cytokine elevation, with gene expression patterns suggesting innate immune hyperactivity.
  • IL-1 receptor antagonism led to sustained suppression of autoinflammatory attacks.
  • Neurologic recovery was observed.

Conclusions:

  • CFI deficiency can present as fulminant, relapsing CNS autoinflammation, potentially triggered by infections.
  • Genetic testing is crucial for diagnosing unexplained neuroinflammation.
  • Targeted therapy with IL-1 receptor antagonists can be effective in managing this rare and severe condition, improving outcomes.