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Enhancing Readability of Lay Abstracts and Summaries for Urologic Oncology Literature Using Generative Artificial
Conner Ganjavi1,2, Ethan Layne1,2, Francesco Cei1,2,3
1USC Institute of Urology and Catherine and Joseph Aresty Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA.
JCO Clinical Cancer Informatics
|September 10, 2025
Summary
Generative artificial intelligence (GAI) creates highly readable lay abstracts and summaries (LASs) for urologic oncology research, improving patient comprehension and perception. Human oversight is crucial for accuracy.
Area of Science:
- Urologic Oncology
- Artificial Intelligence in Medicine
- Scientific Communication
Background:
- Original abstracts (OAs) in urologic oncology can be challenging for patients and caregivers to understand.
- Effective communication of research findings is vital for patient engagement and informed decision-making.
Purpose of the Study:
- To assess a generative artificial intelligence (GAI) framework for generating accurate, clear, and readable lay abstracts and summaries (LASs) of urologic oncology research.
- To evaluate patient and caregiver comprehension and perception of GAI-generated LASs compared to OAs.
Main Methods:
- Forty urologic oncology OAs were used to generate LASs with a GAI tool.
- Readability metrics compared LASs and OAs; independent reviewers assessed accuracy, completeness, and clarity.
- A pilot study involved 277 patients/caregivers randomly assigned to read either OAs or LASs, followed by comprehension and perception assessments.
Main Results:
- GAI-generated LASs were created in under 10 seconds with high quality (85-100%) and minimal hallucinations (1%).
- LASs demonstrated significantly better readability (68.9 vs 25.3) and grade level compared to OAs.
- Patients and caregivers receiving LASs showed significantly improved comprehension and perception (P < .001).
Conclusions:
- GAI-generated LASs are highly readable and maintain research quality for urologic oncology.
- LASs significantly enhance patient and caregiver comprehension and perception compared to original abstracts.
- Human oversight is essential to ensure the accuracy and completeness of GAI-generated scientific summaries.

