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Ln-MOF based magnetic composite nanosensor for sensitive dual-mode fluorescence/colorimetric detection of
Fukai Li1, Jian Zhou1, Kai Li1
1Institute of Quality Standard and Testing Technology for Agro-products, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Abstract:
Fluoroquinolones are a popular class of antibiotics, which can lead to residues in food and the environment due to their abuse and illegal use. Consequently, this can pose a threat to human health. We hypothesized that a core-shell structured magnetic lanthanide metal-organic framework could serve as an effective dual-mode nanosensor, leveraging its antenna effect and peroxidase (POD)-like activity for the sensitive detection of fluoroquinolones. Herein, a novel Fe₃O₄@EuMOF-based platform was developed to establish a rapid and sensitive fluorescence/colorimetric dual-mode method for detecting fluoroquinolones. The established method demonstrated excellent sensitivity for fluoroquinolones with limit of detections (LODs) of 18.6 nM (fluorescence) and 37.5 nM (colorimetric). Furthermore, this novel method has been successfully applied to detect fluoroquinolones in various food matrix sample with significant recoveries (87.3-107.9 %) and relative standard deviations (RSD) of <8 %. This research provided a sensitive and accurate sensing platform for monitoring fluoroquinolones in various food samples.
Insights
A new dual-mode nanosensor detects fluoroquinolone antibiotic residues in food. This magnetic metal-organic framework offers sensitive fluorescence and colorimetric detection, ensuring food safety.
Area of Science:
- Analytical Chemistry
- Materials Science
- Environmental Science
Background:
- Fluoroquinolone antibiotics are widely used but their residues in food and environment pose human health risks.
- Abuse and illegal use of fluoroquinolones contribute to environmental contamination.
- Sensitive detection methods are crucial for monitoring fluoroquinolone contamination.
Purpose of the Study:
- To develop a novel core-shell structured magnetic lanthanide metal-organic framework (MOF) as a dual-mode nanosensor.
- To establish a rapid and sensitive fluorescence/colorimetric method for fluoroquinolone detection.
- To provide an effective platform for monitoring fluoroquinolone residues in food samples.
Main Methods:
- Synthesis of a Fe₃O₄@EuMOF core-shell magnetic nanomaterial.
- Development of a dual-mode sensing strategy utilizing the antenna effect and peroxidase-like activity.
- Validation of the method using fluorescence and colorimetric detection.
- Application of the method to real food matrix samples.
Main Results:
- The Fe₃O₄@EuMOF platform demonstrated sensitive detection of fluoroquinolones.
- Achieved limits of detection (LODs) of 18.6 nM (fluorescence) and 37.5 nM (colorimetric).
- Successfully applied to detect fluoroquinolones in various food samples with high recoveries (87.3-107.9%) and low RSD (<8%).
Conclusions:
- The developed Fe₃O₄@EuMOF-based dual-mode nanosensor is effective for sensitive and accurate fluoroquinolone detection.
- This sensing platform offers a promising tool for food safety monitoring.
- The study highlights the potential of MOFs in environmental and food analysis.
