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Updated: May 11, 2026
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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
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Axonal degeneration in hemorrhagic stroke: A systematic review
Amir Pasokh1, Lamija Hadziavdic2, Tracy D Farr3
1University of Vienna, Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, Vienna, Austria; Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.
Pharmacological Research
|September 10, 2025
Summary
Axonal degeneration (AxD) is a secondary injury following hemorrhagic stroke. This review highlights AxD
Area of Science:
- Neuroscience
- Neurology
- Pathology
Background:
- Hemorrhagic stroke involves brain blood vessel rupture, causing initial mechanical damage and secondary injuries like axonal degeneration (AxD).
- Axons are crucial for brain function, making AxD a significant complication after intracerebral hemorrhage and subarachnoid hemorrhage.
Conclusions:
- AxD is a significant secondary injury in hemorrhagic stroke, developing early and correlating with disease severity.
- Therapeutic strategies targeting neuroinflammation, energy metabolism, microtubule stability, and axonal regeneration show promise.
- Further research is required to translate these strategies into effective clinical interventions for hemorrhagic stroke patients.
Keywords:
Axonal degenerationBeta-amyloid precursor proteinBiomarkersHemorrhagic strokeNeurofilamentNeuroinflammationTauMore Related Videos
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