Related Experiment Video
Updated: Jan 18, 2026
![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)
Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Caseazins R-Y, cytotoxic podocarpane diterpenoids from Casearia kurzii
Xue-Wen Wu1, Qiong Wei1, Xia Pu1
1Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, School of Chemical Science and Technology, School of Medicine and School of Pharmacy, Yunnan University, Kunming, 650091, PR China.
Abstract:
In the present study, eight undescribed compounds, namely caseazins R-Y (1-8) were isolated from the twigs and leaves of Casearia kurzii (Flacourtiaceae). Their structures were elucidated by extensive spectroscopic analysis, nuclear magnetic resonance methods, X-ray diffraction analysis, and ECD calculations. Compound 1 was characterized as a rare 2,3-seco podocarpane carbon skeleton. While compound 8 was a highly oxygenated podocarpane diterpenoid dimer with an oxygen bridge between C-2 and C-11'. In bioassay, the diterpenoid dimer 8 showed potential cytotoxic activity against colorectal cancer cells (SW-620) with IC50 value of 7.29 ± 0.10 μM. Besides, compound 8 exhibited moderate inhibitory activity against colorectal cancer target PI3KαH1047R.
