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Related Concept Videos

Necrosis01:16

Necrosis

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Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
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Translation01:31

Translation

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Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
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Translation01:31

Translation

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Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
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Lysosomal Hydrolases01:22

Lysosomal Hydrolases

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Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
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Protein Import into the Peroxisomes01:27

Protein Import into the Peroxisomes

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Cells contain membrane-bound organelles called peroxisomes that oxidize organic molecules by transferring hydrogen atoms to oxygen, producing hydrogen peroxide. Peroxisomes enzymatically convert the released hydrogen peroxide into water and oxygen.
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...
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Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

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Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
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Updated: Jan 18, 2026

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

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MAFLD: a ferroptotic disease.

Shaojie Cui1, Jin Ye2

  • 1College of Biomedicine and Health, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China.

Trends in Molecular Medicine
|September 10, 2025
PubMed
Summary
This summary is machine-generated.

Ferroptosis, a cell death pathway, significantly contributes to liver injury in metabolic dysfunction-associated fatty liver disease (MAFLD). Targeting ferroptosis offers a promising therapeutic strategy for MAFLD.

Keywords:
VLDLferroptosishyperoxidized PRDX3lipid peroxidationmonounsaturated fatty acidspolyunsaturated phospholipids

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Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
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Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis
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Mouse Model of Metabolic Dysfunction-Associated Steatotic Liver Disease with Fibrosis

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Hepatology

Background:

  • Metabolic dysfunction-associated fatty liver disease (MAFLD) is a growing health concern.
  • Hepatic injury is a key feature of MAFLD pathogenesis.
  • Ferroptosis, an iron-dependent cell death, is increasingly recognized in liver diseases.

Purpose of the Study:

  • To review the role of ferroptosis in MAFLD.
  • To highlight ferroptosis as a driver of liver injury in MAFLD.
  • To explore ferroptosis as a therapeutic target for MAFLD.

Main Methods:

  • Literature review of ferroptosis and MAFLD.
  • Analysis of ferroptosis-specific markers, such as hyperoxidized peroxiredoxin 3 (PRDX3).
  • Examination of genetic and dietary factors influencing ferroptosis in MAFLD.

Main Results:

  • Ferroptosis, marked by PRDX3, is a significant contributor to liver injury in MAFLD.
  • Emerging evidence links ferroptosis to MAFLD pathogenesis.
  • Dietary fat and genetic variants (e.g., PNPLA3(I148M)) modulate ferroptosis sensitivity in MAFLD.

Conclusions:

  • MAFLD can be viewed as a ferroptotic disease.
  • Understanding ferroptosis in MAFLD provides novel pathogenetic insights.
  • Ferroptosis inhibition is a potential therapeutic avenue for MAFLD.