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Low-Density Lipoprotein Receptor-Related Protein 11 Promotes Proliferation in Lung Adenocarcinoma
Takumi Kiwaki1, Hiroyuki Tanaka2, Makiko Kawaguchi3
1Section of Oncopathology and Morphological Pathology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Cancer Science
|September 10, 2025
Summary
Low-density lipoprotein receptor-related protein 11 (LRP11) promotes lung adenocarcinoma progression by increasing cell proliferation. High LRP11 expression correlates with poor prognosis, suggesting it as a potential therapeutic target and biomarker.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Low-density lipoprotein receptor-related protein 11 (LRP11) is overexpressed in several cancers.
- The specific role of LRP11 in lung adenocarcinoma (LUAD) pathogenesis is not well-defined.
Purpose of the Study:
- To investigate the tumor-promoting function of LRP11 in lung adenocarcinoma.
- To identify molecular mechanisms and clinical relevance of LRP11 in LUAD.
Main Methods:
- LRP11 expression and function were analyzed in LUAD cell lines via silencing and overexpression.
- RNA sequencing identified genes regulated by LRP11.
- Clinical data from TCGA and Singapore Oncology Data Portal assessed LRP11's prognostic value.
Main Results:
- LRP11 overexpression enhanced LUAD cell proliferation in vitro.
- RNA sequencing revealed genes negatively correlated with LRP11, featuring C/EBPβ binding motifs.
- High LRP11 expression was significantly associated with poorer patient prognosis in LUAD.
Conclusions:
- LRP11 drives LUAD progression through enhanced cell proliferation and transcriptional modulation.
- LRP11 represents a potential therapeutic target and prognostic biomarker for lung adenocarcinoma.
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