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An electron microscope study of the perfusion-fixed spleen. II. Fine structure of the sinus lining cells with respect
Anatomischer Anzeiger
|January 1, 1977
Abstract:
In the perfusion-fixed spleen of monkey (Macaca mulatta) were studied with the electron microscope the cytoplasmatic structures of the sinus lining cells. The particular interest find the contractile filaments in this cells, which are important for the cell contraction. The connections to the smooth endoplasmatic reticulum are very strong as in the muscle fiber or muscle cell.
Insights
Electron microscopy revealed contractile filaments in monkey spleen sinus lining cells, similar to muscle cells. These structures are crucial for cell contraction and spleen function.
Area of Science:
- Cell Biology
- Microscopy
- Primate Anatomy
Background:
- The spleen's sinus lining cells play a role in immune responses and blood filtration.
- Understanding the cellular mechanisms of spleen function is vital for hematology and immunology.
Purpose of the Study:
- To investigate the ultrastructure of splenic sinus lining cells in Macaca mulatta.
- To identify and characterize contractile elements within these cells.
Main Methods:
- Perfusion-fixation of spleen tissue from Macaca mulatta.
- High-resolution electron microscopy of cytoplasmatic structures.
Main Results:
- Identified distinct contractile filaments within the cytoplasm of splenic sinus lining cells.
- Observed strong connections between these filaments and the smooth endoplasmic reticulum.
- Noted similarities to contractile apparatus found in muscle fibers and cells.
Conclusions:
- Splenic sinus lining cells possess contractile capabilities mediated by specialized filaments.
- These contractile elements, linked to the endoplasmic reticulum, likely contribute to spleen's mechanical functions.