Related Experiment Video
Updated: May 12, 2026
10:38
DIPLOMA Approach for Standardized Pathology Assessment of Distal Pancreatectomy Specimens
Published on: February 1, 2020
7.9K
Association between the English National Health Service Diabetes Prevention Programme and incident multiple long-term
Emma Barron1,2,3, Paul Chappell3, Izzy Hatfield3
1Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.
Nature Medicine
|September 10, 2025
Summary
Completing the National Health Service Diabetes Prevention Programme (NHS DPP) is linked to lower risks of type 2 diabetes and other long-term conditions. These benefits persist for at least 24 months post-program completion.
Area of Science:
- Public Health
- Preventive Medicine
- Epidemiology
Background:
- The National Health Service Diabetes Prevention Programme (NHS DPP) aims to reduce type 2 diabetes (T2D) risk through lifestyle interventions.
- Previous studies show NHS DPP completion correlates with reduced body weight, HbA1c, and T2D incidence.
Purpose of the Study:
- To investigate the association between NHS DPP completion and the incidence of T2D and 30 other long-term conditions (LTCs).
- To differentiate between LTCs directly linked (LTC-L) and possibly linked (LTC-PL) to the program's intervention goals.
Main Methods:
- Retrospective cohort study comparing NHS DPP completers with non-attenders.
- Analysis of T2D incidence and 30 other LTCs, categorized as LTC-L and LTC-PL.
- Longitudinal analysis of outcomes up to 24 months post-completion.
Main Results:
- NHS DPP completers exhibited lower incidences of T2D, LTC-L, and LTC-PL compared to non-attenders.
- These associations remained statistically significant at 24 months.
- Odds ratio for T2D was 0.53 (95% CI: 0.48-0.59); rate ratios for LTC-L and LTC-PL were 0.79 (0.74-0.84) and 0.80 (0.74-0.88), respectively.
Conclusions:
- Completion of the NHS DPP is associated with reduced incidence of T2D and related long-term conditions.
- While associations attenuated over time, they remained significant at 24 months.
- Causality cannot be definitively concluded due to potential residual confounding and diagnostic imprecision.
More Related Videos
Related Concept Videos
01:30Preventive Healthcare Services
Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
01:26Levels of Health Promotion and Illness Prevention
Health promotion allows a person to control the determinants of health, resulting in an improved health status. It enhances the quality of life and reduces premature deaths. Health promotion and illness prevention programs help people make beneficial choices to reduce the risk of disease and disabilities. There are three health promotion and illness prevention levels: primary, secondary, and tertiary prevention.
In primary prevention, actions taken before disease onset prevent the disease from...
In primary prevention, actions taken before disease onset prevent the disease from...
01:22Nursing Diagnosis
Following assessment, a nursing diagnosis is the next step in the nursing process. It begins after the nurse has collected and recorded the patient data. The purpose of diagnosing is to identify how the client responds to actual or potential health processes, identify factors that bestow or that cause health problems, the etiologies, and identify resources or strengths the individual, group, or community can draw on to prevent or resolve problems.
The nursing diagnosis focuses on evidence-based...
The nursing diagnosis focuses on evidence-based...
01:22Diabetes Mellitus: Type 2 and Gestational
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
01:15Diabetes: Symptoms, Diagnosis, and Complications
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...
01:28Diabetic Nephropathy
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...