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Related Experiment Video

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Cognitive Compensation Depends on Frontoparietal Network Structure-Function Coupling in Patients With White Matter

Xiao Zhu1, Yifei Li1, Ying Zhou1

  • 1Department of Neurology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.

Brain and Behavior
|September 11, 2025
PubMed
Summary

Network structure-function coupling (SC-FC coupling) in the frontoparietal network may help maintain cognition in early white matter hyperintensity (WMH) stages. This finding suggests SC-FC coupling could be a target for interventions to preserve cognitive function in WMH patients.

Keywords:
cognitioncompensationdiffusion tensor imagingfunctional MRIwhite matter hyperintensity

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Area of Science:

  • Neuroimaging
  • Cognitive Neuroscience
  • Cerebrovascular Disease Research

Background:

  • White matter hyperintensity (WMH) is linked to cognitive decline, but early-stage mechanisms remain unclear.
  • Investigating network structure-function coupling (SC-FC coupling) is crucial for understanding early WMH impacts on cognition.

Purpose of the Study:

  • To explore the role of network SC-FC coupling in the cognitive performance of patients with WMH.
  • To determine if SC-FC coupling patterns differ between mild and severe WMH stages and correlate with cognitive function.

Main Methods:

  • Retrospective analysis of 617 WMH patients from the CIRCLE study using multimodal MRI and cognitive assessments.
  • Calculation of network SC-FC coupling from diffusion tensor imaging and functional MRI data.
  • Classification of WMH severity based on Fazekas scores for periventricular and deep WMH.

Main Results:

  • The frontoparietal network showed the lowest SC-FC coupling, while the somatomotor network had the highest across all participants.
  • In mild WMH, frontoparietal SC-FC coupling positively correlated with WMH volume and cognitive performance on the digit span forward task.
  • These correlations were not observed in the whole cohort or the severe WMH subgroup.

Conclusions:

  • Frontoparietal network SC-FC coupling may facilitate cognitive compensation in the early stages of WMH.
  • SC-FC coupling represents a potential therapeutic target for interventions aimed at preserving cognitive function in WMH patients.