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Zhenbang Chang¹, Arushi Garg¹, Tatiana Besset¹

¹INSA Rouen Normandie, Univ Rouen Normandie, Univ Caen Normandie, ENSICAEN, CNRS, Institut CARMeN (UMR 6064), F-76000 Rouen, France. tatiana.besset@insa-rouen.fr.

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Summary

Cleaving the aryl C-OCF3 bond is challenging but advances enable new C-C, C-H, and C-heteroatom bond formations. This review highlights progress in activating this strong bond for synthetic chemistry.

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Area of Science:

Organic Chemistry
Synthetic Chemistry

Background:

Trifluoromethoxylated arenes are important synthetic targets.
The cleavage of the aryl C-OCF3 bond is synthetically challenging.
Few methods exist for the selective activation of the C-OCF3 group.

Purpose of the Study:

To review recent advances in the activation of the aryl C-OCF3 bond.
To highlight methods enabling C-C, C-H, and C-heteroatom bond formations.
To underscore the potential of this emerging field in synthetic chemistry.

Main Methods:

Review of literature on C-OCF3 bond activation.
Analysis of key synthetic transformations.
Categorization of bond formation strategies.

Main Results:

Significant progress has been made in activating the strong aryl C-OCF3 bond.
Novel methodologies enable the formation of new carbon-carbon bonds.
Methods for C-H and C-heteroatom bond formation have been developed.

Conclusions:

The activation of the aryl C-OCF3 bond is a rapidly developing area.
These advances offer new synthetic routes and possibilities.
Further research holds transformative potential for organic synthesis.