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Improving Representation of Underserved Populations in Cardiovascular Research
Irving K Loh1, Tyler E Miller2, Rahul Aggarwal3
1Ventura Heart Institute Thousand Oaks CA USA.
Journal of the American Heart Association
|September 11, 2025
Summary
Cardiovascular disease disproportionately affects underserved populations. Increasing clinical trial diversity through community engagement and decentralized trials is crucial for equitable care and personalized medicine.
Area of Science:
- Cardiovascular Medicine
- Health Equity
- Clinical Research
Background:
- Cardiovascular disease is the leading cause of death in the U.S.
- Medically underserved populations face higher risks and are underrepresented in clinical trials.
- This underrepresentation exacerbates health inequities in cardiovascular care.
Purpose of the Study:
- To review the importance of including underserved populations in cardiovascular clinical research.
- To identify key barriers to participation for these groups.
- To explore strategies for improving representation.
Main Methods:
- Review of existing literature on cardiovascular clinical trials and underserved populations.
- Exploration of system-level strategies like community-engaged research and clinical trial decentralization.
- Discussion of workforce diversity and stakeholder involvement in study design and administration.
Main Results:
- Underserved populations remain critically underrepresented in cardiovascular clinical trials.
- Decentralized trials and community engagement show feasibility for increasing access.
- Workforce diversity and stakeholder input can enhance representation.
Conclusions:
- Improving diversity in cardiovascular clinical trials is essential for ensuring treatment effectiveness across all populations.
- Strategies such as decentralized trials, community engagement, and diverse workforces are key.
- A holistic, hub-and-spoke model is proposed to enhance participant diversity.
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