Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic impact of concomitant leptomeningeal disease in breast cancer patients with brain metastases: a large single-center cohort study.

Journal of neuro-oncology·2026
Same author

Minimally invasive tubular retractor implantation of a paddle electrode stimulator for the trigeminal nucleus caudalis: illustrative case.

Journal of neurosurgery. Case lessons·2026
Same author

Surgical management of ossified posterior longitudinal ligament: a review.

British journal of neurosurgery·2026
Same author

An updated review on systemic therapy for brain metastases in non-small cell lung cancer.

Translational cancer research·2026
Same author

Assessing progesterone receptor modulation in glioblastoma: from <i>in vitro</i> and animal model to a human pilot protocol.

Cancer biology & therapy·2025
Same author

Integrated Multi-Omics Approaches for Predicting Immune Checkpoint Inhibitor Response in NSCLC - Insights From Genomics, Proteomics, and Metabolomics.

Lung Cancer (Auckland, N.Z.)·2025

Related Experiment Video

Updated: Jan 18, 2026

Laser Capture Microdissection of Glioma Subregions for Spatial and Molecular Characterization of Intratumoral Heterogeneity, Oncostreams, and Invasion
09:09

Laser Capture Microdissection of Glioma Subregions for Spatial and Molecular Characterization of Intratumoral Heterogeneity, Oncostreams, and Invasion

Published on: April 12, 2020

7.4K

Understanding glioma pathogenesis through ultrastructural analysis.

Muhammad Sulman1, John Paul Aboubechara2, Mones S Abu-Asab3

  • 1School of Medicine, University of California, Davis, CA, USA.

Ultrastructural Pathology
|September 11, 2025
PubMed
Summary

Ultrastructural analysis reveals lipid accumulation, mitochondrial and membrane abnormalities, and vascular changes in gliomas. These findings offer insights into glioma pathology and potential therapeutic strategies.

Keywords:
Electron microscopyIDH1-mtIDH1-wtglioblastoma multiformegliomaultrastructural pathology

More Related Videos

Translational Orthotopic Models of Glioblastoma Multiforme
07:37

Translational Orthotopic Models of Glioblastoma Multiforme

Published on: February 17, 2023

3.6K
Imaging Glioma Initiation In Vivo Through a Polished and Reinforced Thin-skull Cranial Window
09:44

Imaging Glioma Initiation In Vivo Through a Polished and Reinforced Thin-skull Cranial Window

Published on: November 20, 2012

13.6K

Related Experiment Videos

Last Updated: Jan 18, 2026

Laser Capture Microdissection of Glioma Subregions for Spatial and Molecular Characterization of Intratumoral Heterogeneity, Oncostreams, and Invasion
09:09

Laser Capture Microdissection of Glioma Subregions for Spatial and Molecular Characterization of Intratumoral Heterogeneity, Oncostreams, and Invasion

Published on: April 12, 2020

7.4K
Translational Orthotopic Models of Glioblastoma Multiforme
07:37

Translational Orthotopic Models of Glioblastoma Multiforme

Published on: February 17, 2023

3.6K
Imaging Glioma Initiation In Vivo Through a Polished and Reinforced Thin-skull Cranial Window
09:44

Imaging Glioma Initiation In Vivo Through a Polished and Reinforced Thin-skull Cranial Window

Published on: November 20, 2012

13.6K

Area of Science:

  • Neuro-oncology
  • Cellular pathology
  • Tumor microenvironment research

Background:

  • Gliomas are the most common malignant brain tumors, originating from glial cells.
  • Glioblastoma, a type of glioma, has a poor prognosis with an average survival of 15 months.
  • Understanding glioma ultrastructure and microenvironment is crucial for advancing treatment.

Purpose of the Study:

  • To analyze recent developments in the ultrastructural pathology of gliomas.
  • To highlight the role of lipid accumulation and associated cellular changes.
  • To examine vascular abnormalities and microenvironmental features in gliomas.

Main Methods:

  • High-resolution electron microscopy for ultrastructural analysis (UA).
  • Examination of cellular and subcellular characteristics.
  • Analysis of tumor microenvironment, including vascular structures and cellular components.

Main Results:

  • Abundant intracellular and extracellular lipids observed in gliomas.
  • Aberrant mitochondrial structures and disrupted cellular membranes noted.
  • Significant vascular disruptions, including atypical vessel walls and tumor cell mimicry of endothelial cells.
  • High prevalence of multinucleated giant cells and extrachromosomal DNA in the microenvironment.

Conclusions:

  • Ultrastructural analysis provides critical insights into glioma pathogenesis.
  • Lipid alterations, mitochondrial dysfunction, and vascular anomalies are key features.
  • Findings have implications for future glioma research, diagnostics, and therapeutics.