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Profile of Patients with Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Single-Center Study
Fatima K Alduraibi1,2,3, James Haigney1, Natalya Surmachevska1
1Division of Clinical Immunology and Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA.
European Journal of Rheumatology
|September 11, 2025
Summary
Patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD) treated for their condition showed lung stability or improvement at six and twelve months. However, high patient dropout and limited follow-up restricted further analysis of RA-ILD progression factors.
Area of Science:
- Rheumatology
- Pulmonology
- Medical Research
Background:
- Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a known complication of rheumatoid arthritis (RA).
- Understanding RA-ILD characteristics, treatment, and outcomes is crucial for patient management.
Purpose of the Study:
- To describe the characteristics, treatment strategies, and 6- and 12-month outcomes of patients with RA-ILD.
- To identify factors associated with RA-ILD progression.
Main Methods:
- Retrospective analysis of 47 RA-ILD patients diagnosed between 2010-2019.
- Inclusion criteria included ICD codes for RA and ILD, and ACR/EULAR classification criteria.
- Diagnosis confirmed by clinical features, pulmonary function testing (PFT), and high-resolution computed tomography (HRCT).
Main Results:
- 48.9% of patients received RA-ILD treatment.
- At 6 and 12 months, 90.6% and 88.9% of patients, respectively, showed stability or improvement in lung disease.
- Tobacco use was associated with RA-ILD progression at 6 months (P=.025).
Conclusions:
- Treatment for RA-ILD appears to correlate with lung disease stability or improvement at 6 and 12 months.
- High attrition rates and short follow-up periods limited the identification of additional prognostic factors for RA-ILD.
- Further research with longer follow-up is warranted to fully understand RA-ILD progression.
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