Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Blood-brain Barrier

The Blood-brain Barrier

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

An Improved Brain-Penetrating Nanoformulation of the VIPR2 Antagonist Peptide KS-133 for Treating Cognitive Impairment in Schizophrenia.

Biological & pharmaceutical bulletin·2026

Same author

Epigenetic regulation of hyaluronan degradation and melanogenesis by Kawarayomogin I and II from Artemisia capillaris via miR-486-5p and miR-141-3p.

Molecular biology reports·2026

Same author

NIMA-related kinases redundantly regulate vegetative and reproductive development in Arabidopsis thaliana.

Plant & cell physiology·2026

Same author

Thrombus Age in Ischemic Stroke With Atrial Fibrillation: Impact on Mechanical Thrombectomy.

Stroke (Hoboken, N.J.)·2026

Same author

Discovery and characterization of antitumor gut microbiota from amphibians and reptiles: <i><b>Ewingella americana</b></i> as a novel therapeutic agent with dual cytotoxic and immunomodulatory properties.

Gut microbes·2025

Same author

Systemic administration of <i>Photobacterium angustum</i> promotes antitumor immunity and direct tumor lysis in murine models of colorectal cancer.

Journal for immunotherapy of cancer·2025

Search research articles

Related Experiment Video

Updated: Jan 18, 2026

Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish

Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish

Published on: April 16, 2019

A Next-Generation Brain-Targeting Peptide: KS-487 Rivals Angiopep-2 in BBB Penetration with Enhanced Selectivity.

Kensuke Asukabe¹, Nagi Yamashita¹, Runa Fujimoto²

¹Graduate School of Advanced Science and Technology, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, 923-1292 Ishikawa, Japan.

Bioconjugate Chemistry

|September 11, 2025

Summary

This summary is machine-generated.

KS-487, a cyclic peptide, shows excellent blood-brain barrier permeability and higher brain selectivity than Angiopep-2. This peptide is a promising candidate for targeted drug delivery to the brain with a strong safety profile.

More Related Videos

Setting-up an In Vitro Model of Rat Blood-brain Barrier BBB: A Focus on BBB Impermeability and Receptor-mediated Transport

Setting-up an In Vitro Model of Rat Blood-brain Barrier BBB: A Focus on BBB Impermeability and Receptor-mediated Transport

Published on: June 28, 2014

A Simple Alternative to Stereotactic Injection for Brain Specific Knockdown of miRNA

A Simple Alternative to Stereotactic Injection for Brain Specific Knockdown of miRNA

Published on: December 26, 2015

Related Experiment Videos

Last Updated: Jan 18, 2026

Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish

Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish

Published on: April 16, 2019

Setting-up an In Vitro Model of Rat Blood-brain Barrier BBB: A Focus on BBB Impermeability and Receptor-mediated Transport

Setting-up an In Vitro Model of Rat Blood-brain Barrier BBB: A Focus on BBB Impermeability and Receptor-mediated Transport

Published on: June 28, 2014

A Simple Alternative to Stereotactic Injection for Brain Specific Knockdown of miRNA

A Simple Alternative to Stereotactic Injection for Brain Specific Knockdown of miRNA

Published on: December 26, 2015

Area of Science:

Neuroscience
Pharmacology
Biotechnology

Background:

The blood-brain barrier (BBB) restricts the entry of therapeutic agents into the brain.
Low-density lipoprotein receptor-related protein 1 (LRP1) is a key target for enhancing BBB permeability.
Peptides that bind LRP1 are being investigated for brain drug delivery.

Purpose of the Study:

To compare the in vivo blood-brain barrier (BBB) permeability and brain selectivity of KS-487 with Angiopep-2 (ANG2).
To evaluate the safety profile of KS-487 for potential therapeutic applications.

Main Methods:

Indocyanine green (ICG)-labeled KS-487 and ANG2 were administered subcutaneously to mice.
Biodistribution was assessed using in vivo imaging at 24, 48, and 72 hours.
Brain selectivity was determined by comparing brain and liver accumulation ratios.

Main Results:

ICG-KS-487 and ICG-ANG2 exhibited comparable brain permeability and similar time-course profiles.
ICG-KS-487 demonstrated significantly greater brain selectivity compared to ICG-ANG2.
No adverse effects were observed in mice treated with ICG-KS-487.

Conclusions:

KS-487 possesses superior brain-targeting properties and a favorable safety profile.
KS-487 shows potential as an effective targeting ligand for drug delivery across the BBB for brain disorders.