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TauroSept-Induced Anaphylaxis: A Pediatric Case Report
Elise Mank1, Nancy Broos2, Ingrid Terreehorst3
1Department of Pediatrics, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Pediatric Allergy, Immunology, and Pulmonology
|September 11, 2025
Summary
TauroSept®, a taurolidine lock solution, is generally safe for children receiving parenteral nutrition. However, this case highlights a rare instance of anaphylaxis in an infant, emphasizing the need for clinical awareness of potential side effects.
Area of Science:
- Pediatric Gastroenterology
- Clinical Pharmacology
Background:
- Children with intestinal failure require parenteral nutrition via central venous catheters, increasing their risk of catheter-related bloodstream infections.
- Taurolidine lock solutions have been widely used for prophylaxis against these infections and are generally considered safe in pediatric populations.
Purpose of the Study:
- To report the first documented case of anaphylaxis in an infant following the administration of TauroSept® (taurolidine).
Main Methods:
- A case report detailing a 1-month-old infant with jejunal atresia receiving parenteral nutrition.
- Observation of adverse events, including circulatory insufficiency and angioedema, shortly after TauroSept® administration.
- Measurement of serum tryptase levels to assess for anaphylaxis.
Main Results:
- The infant developed severe symptoms consistent with anaphylaxis after TauroSept® administration.
- Serum tryptase levels showed a significant increase, confirming the allergic reaction.
- The event suggests a rare but serious adverse reaction to taurolidine in an infant.
Conclusions:
- This case represents the first reported instance of anaphylaxis to TauroSept® in an infant globally.
- Healthcare providers should maintain awareness of this potential, albeit rare, side effect when using taurolidine lock solutions in pediatric patients.
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