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Topical Anesthesia and Olfactory Capability: A Pilot Study.

Maxime Fieux1,2,3,4, Esther Wang5, David T Liu4

  • 1Hospices Civils de Lyon, Centre Hospitalier Lyon Sud Service D'ORL, D'otoneurochirurgie et de Chirurgie Cervico-Faciale Lyon France.

Laryngoscope Investigative Otolaryngology
|September 11, 2025
PubMed
Summary
This summary is machine-generated.

Topical anesthesia (TA) temporarily impairs olfactory function, as measured by the University of Pennsylvania Smell Identification Test (UPSIT). Olfactory capability fully recovers within 10 minutes after nasal administration of TA in healthy volunteers.

Keywords:
olfaction disordersolfactory losssmelltherapeuticstopical anesthesia

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Area of Science:

  • Otolaryngology
  • Neuroscience
  • Anesthesiology

Background:

  • Topical anesthesia (TA) is commonly used for patient comfort during nasal endoscopy.
  • The duration of TA's effect on olfactory function is not well-established, impacting the timing of olfactory testing.
  • Accurate olfactory assessment requires understanding when TA's effects subside.

Purpose of the Study:

  • To determine the time course of olfactory capability recovery after intranasal TA administration in healthy volunteers.
  • To establish the optimal window for olfactory testing post-TA application.

Main Methods:

  • A prospective, single-center pilot study involving 30 healthy volunteers.
  • Olfactory function was assessed using the University of Pennsylvania Smell Identification Test (UPSIT) at baseline and at three time points after TA administration: immediately (T0), 10 minutes (T+10), and 30 minutes (T+30).
  • Statistical analysis included paired t-tests to compare UPSIT scores across time points.

Main Results:

  • Immediately after TA administration (T0), UPSIT scores were significantly lower than baseline, indicating impaired olfactory function.
  • Olfactory function, as measured by UPSIT scores, significantly recovered by the 10-minute mark (T+10) and showed no significant difference from baseline.
  • UPSIT scores at 30 minutes (T+30) also showed no significant difference from baseline, confirming olfactory recovery.

Conclusions:

  • Intranasal topical anesthesia significantly impairs olfactory function immediately after administration.
  • Olfactory capability is fully recovered by 10 minutes post-TA application, allowing for accurate olfactory testing.
  • These findings provide crucial timing guidance for olfactory assessments following nasal procedures involving TA.