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Related Experiment Video

Updated: Jan 18, 2026

Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models
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miR-872 Protection Against Renal Ischemia-Reperfusion Injury via Targeting HMOX1.

Jiang Wei1, Zhang L Feng1, Cheny Y Mao1

  • 1Urology, Ezhou Central Hospital, Ezhou, CHN.

Cureus
|September 11, 2025
PubMed
Summary

MicroRNA-872 (miR-872) protects against kidney ischemia-reperfusion injury (RIRI) by downregulating HMOX1. This discovery offers a novel therapeutic strategy for RIRI by targeting miRNA levels.

Keywords:
apoptosisbiomarkerhmox1ischemia reperfusion injurymir-872mirna-mrna network

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Area of Science:

  • Nephrology
  • Molecular Biology
  • Transplantation Immunology

Background:

  • Renal ischemia-reperfusion (IR) is a critical factor in acute kidney injury (AKI) following kidney transplantation.
  • Understanding the molecular mechanisms of renal IR injury (RIRI) is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the role of the microRNA-messenger RNA (miRNA-mRNA) network in the pathogenesis of RIRI.
  • To identify specific miRNAs and their targets involved in RIRI.

Main Methods:

  • Established rat models of renal IR and cellular models of hypoxia/reoxygenation (H/R).
  • Assessed AKI using renal histology and blood urea nitrogen (BUN) levels.
  • Utilized functional assays to determine the role of miR-872 and its downstream target, HMOX1.

Main Results:

  • A significant decrease in miR-872 was observed in both in vivo and in vitro RIRI models.
  • Downregulation of miR-872 exacerbated RIRI, while its upregulation (using angomir) impeded cell apoptosis.
  • HMOX1 was identified as a direct downstream target of miR-872.

Conclusions:

  • miR-872 plays a protective role in mitigating RIRI by downregulating HMOX1 expression.
  • Modulating miR-872 levels presents a potential therapeutic strategy for treating RIRI.