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Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
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Within and beyond the tumor: Mechanisms of glioblastoma-induced immunosuppression
Bhairavy J Puviindran1,2, Shannon Wallace1,2, Katayoun Ayasoufi3,4
1Brain Tumor Immunotherapy Program, Duke University, Durham, North Carolina.
Abstract:
Immunotherapies have thus far proved of limited efficacy against glioblastoma. Failures can be attributed to a host of immunosuppressive mechanisms that are either directly employed by the tumor or are instead a convenient feature of the intracranial environment. This review aims to categorize glioblastoma immune-evasive tendencies, provide an update on our understanding of etiologies, and describe newer approaches to improving therapeutic responses.
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