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Cellular immunotherapies for central nervous system cancers.
Brian J Scott1, Michelle Monje2,1
1Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Neuro-Oncology Advances
|September 11, 2025
Summary
Cellular immunotherapies, including CAR T and CAR NK cells, show promise for treating central nervous system cancers like glioblastoma. Further research is needed to overcome treatment failures and advance these therapies for brain and spinal cord tumors.
Area of Science:
- Oncology
- Immunology
- Neuroscience
Background:
- Cellular immunotherapies have revolutionized hematologic malignancy treatment.
- These therapies hold potential for central nervous system (CNS) cancers.
Purpose of the Study:
- To review cellular therapeutics for CNS cancers.
- Focus on glioblastoma, diffuse intrinsic pontine glioma/diffuse midline glioma, medulloblastoma, and CNS lymphoma.
Main Methods:
- Review of preclinical and clinical studies.
- Examination of CAR T-cell and CAR NK-cell therapies for intracranial tumors.
Main Results:
- Identification of numerous potential therapeutic targets.
- Early clinical trials demonstrate safety and feasibility of CAR T/NK cells for intracranial tumors.
Conclusions:
- Cellular immunotherapies offer a promising avenue for CNS cancer treatment.
- Addressing treatment failure mechanisms and advancing promising therapies are crucial for improving outcomes in challenging CNS cancers.
Keywords:
cellular immunotherapychimeric antigen receptor T cellchimeric antigen receptor natural killer celldiffuse intrinsic pontine glioma/diffuse midline gliomaglioblastomaMore Related Videos
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