Post-traumatic myelin oligodendrocyte glycoprotein antibody optic neuritis: A case report

Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) has recently been distinguished as its own disease entity separate from other demyelinating diseases. This case report highlights the possible association of orbital trauma with the development of MOG antibody (MOG-IgG) optic neuritis.

A 31-year-old male with no significant ocular history presented with blurry vision in the right eye four weeks after a motorcycle crash. Right eye examination was notable for a significant decrease in visual acuity with a relative afferent pupillary defect and circumferential disc elevation on fundoscopy. An extensive workup, including imaging and serology, revealed optic neuritis with a positive MOG-IgG antibody titer. The patient was treated with intravenous steroids followed by an oral taper, with near-complete resolution of his symptoms.

MOG antibody-related optic neuritis should be considered in patients presenting with painful vision loss after trauma, as early recognition and treatment can lead to favorable outcomes.