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Related Concept Videos

Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
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The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
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Diversity of Antigen Receptors01:28

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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
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Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
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Related Experiment Video

Updated: Jan 18, 2026

Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization
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CD47/SIRPα pathways: Functional diversity and molecular mechanisms.

Nitin Bhardwaj1, Harish Chandra2, Ashutosh Singh3

  • 1Department of Zoology and Environmental Sciences, Gurukula Kangri (Deemed to be University), Haridwar 249404, India. nitindna2001@gmail.com.

World Journal of Biological Chemistry
|September 11, 2025
PubMed
Summary
This summary is machine-generated.

CD47, a cell surface protein, regulates cell functions and interactions. Targeting the CD47/SIRPα pathway offers promising cancer therapies by modulating immune responses against tumors.

Keywords:
CD47CancerErythrocyteImmunitySignal regulatory protein α

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Area of Science:

  • Cellular Biology
  • Immunology
  • Oncology

Background:

  • Cellular communication is vital for homeostasis, mediated by cell surface receptors.
  • Integrins are transmembrane receptors crucial for cell adhesion and signaling.
  • CD47 (cell surface protein) regulates integrin function and interacts with SIRPα.

Purpose of the Study:

  • To review the multifunctional roles of CD47.
  • To elucidate the molecular mechanisms of CD47/SIRPα interactions.
  • To discuss therapeutic strategies targeting CD47/SIRPα in cancer.

Main Methods:

  • Literature review of studies on CD47 and SIRPα.
  • Analysis of CD47's role in cell adhesion, signaling, and immune evasion.
  • Examination of clinical trial data for anti-CD47 therapies.

Main Results:

  • CD47 interacts with SIRPα, influencing adhesion, apoptosis, phagocytosis, proliferation, and metabolism.
  • Increased CD47 expression in tumor cells helps them evade immune surveillance.
  • Anti-CD47 antibodies demonstrate therapeutic potential in hematologic and solid tumors.

Conclusions:

  • CD47 plays diverse roles in cellular functions and cancer progression.
  • The CD47/SIRPα axis is a critical target for cancer immunotherapy.
  • Targeting CD47 presents a promising strategy for treating various malignancies.