Alcohol consumption, high-sensitivity C-reactive protein, and estimated glomerular filtration rate: tripartite predictors of 10-year cardiovascular risk progression in patients with type 2 diabetes mellitus after COVID-19
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View abstract on PubMed
Summary
This summary is machine-generated.COVID-19 infection increases 10-year cardiovascular disease (CVD) risk in type 2 diabetes patients. Alcohol consumption and high-sensitivity C-reactive protein (hs-CRP) are key predictors, while eGFR is protective.
Area Of Science
- Cardiology
- Endocrinology
- Infectious Diseases
Background
- Type 2 diabetes (T2D) patients face elevated cardiovascular disease (CVD) risk.
- Corona Virus Disease 2019 (COVID-19) infection may exacerbate CVD risk in T2D.
- Understanding post-COVID-19 CVD risk factors in T2D is crucial for intervention.
Purpose Of The Study
- Investigate predictors of 10-year CVD risk progression in T2D patients post-COVID-19.
- Inform early intervention strategies for the cardiovascular aspect of cardiovascular-kidney-metabolic (CKM) syndrome.
Main Methods
- Retrospective cohort analysis of 378 T2D patients.
- Assessed 10-year CVD risk progression using the SCORE2-Diabetes system.
- Employed logistic regression, restricted cubic spline (RCS) analysis, and AUC for predictive modeling.
Main Results
- 12.2% of patients showed increased 10-year CVD risk post-COVID-19.
- Alcohol consumption (OR 2.10), hs-CRP (OR 1.33), and eGFR (OR 0.96) significantly predicted CVD risk progression.
- A threshold effect was observed for hs-CRP at 3.0 mg/L.
- The combined model of alcohol, hs-CRP, and eGFR achieved the highest predictive accuracy (AUC = 0.749).
Conclusions
- Alcohol consumption and elevated hs-CRP are associated with increased CVD risk progression in T2D post-COVID-19.
- Higher estimated glomerular filtration rate (eGFR) is linked to reduced CVD risk progression.
- These factors are vital for targeted cardiovascular risk management in T2D patients.
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