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Updated: Jan 18, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
Published on: May 8, 2015
Engineering versatile supramolecular structures with tetravalent DNA-traptavidin building blocks
Dayoung Gloria Lee1,2, Young-Youb Kim1, Hoonil Yang1
1Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University Seoul 08826 Republic of Korea songyk@snu.ac.kr.
Abstract:
Proteins offer great promise for nanoscale biomaterials, but precise assembly is challenging. This study presents DNA-protein hybrid building blocks (DTHBs) using traptavidin and biotinylated DNA for controlled assembly to linear chains, spherical clusters, and ordered lattices, enabling sophisticated, programmable architectures with potential biomedical applications, including drug delivery and biosensors.

