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Updated: Jan 18, 2026
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Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
Published on: May 8, 2015
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Engineering versatile supramolecular structures with tetravalent DNA-traptavidin building blocks.
Dayoung Gloria Lee1,2, Young-Youb Kim1, Hoonil Yang1
1Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University Seoul 08826 Republic of Korea songyk@snu.ac.kr.
Nanoscale Advances
|September 11, 2025
Summary
This study introduces DNA-protein hybrid building blocks for precise nanoscale assembly. These programmable biomaterials enable controlled formation of chains, clusters, and lattices for biomedical applications.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Molecular Engineering
Background:
- Proteins are promising for nanoscale biomaterials but face assembly challenges.
- Precise control over protein arrangement is crucial for advanced material properties.
Purpose of the Study:
- To develop DNA-protein hybrid building blocks (DTHBs) for controlled nanoscale assembly.
- To demonstrate the programmability of DTHBs for creating diverse architectures.
Main Methods:
- Utilized traptavidin and biotinylated DNA to create DTHBs.
- Engineered controlled self-assembly into linear chains, spherical clusters, and ordered lattices.
Main Results:
- Successfully created programmable DNA-protein hybrid building blocks.
- Demonstrated precise control over assembly into various architectures (chains, clusters, lattices).
- Achieved sophisticated, programmable architectures using DTHBs.
Conclusions:
- DNA-protein hybrid building blocks offer a versatile platform for nanoscale biomaterial construction.
- Programmable architectures have potential applications in drug delivery and biosensors.
- This approach overcomes challenges in precise protein assembly for advanced biomaterials.
