A Discourse on Percutaneous Closure of the Patent Ductus Arteriosus in Premature Neonates: Controversy, Remedy, or Paradox of Choice?

Wisam Abozaid ¹, Souvik Mitra ², Bonny Jasani ³

⁰Division of Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

Cjc Pediatric and Congenital Heart Disease +

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September 11, 2025

View abstract on PubMed

Summary

Transcatheter closure is a safe, minimally invasive option for patent ductus arteriosus (PDA) in premature infants. This review examines how this procedure impacts clinical decisions in neonatal intensive care units.

Area Of Science

Neonatology
Pediatric Cardiology
Medical Devices

Background

Patent ductus arteriosus (PDA) management in premature neonates is complex.
Historically, surgical closure was the primary intervention, often leading to difficult consensus.
The advent of percutaneous closure has introduced less invasive options.

Purpose Of The Study

To review the current literature on transcatheter PDA closure in premature infants.
To examine the impact of percutaneous PDA closure on clinical decision-making in neonatology.
To assess changes in management strategies with the availability of minimally invasive options.

Main Methods

Comprehensive literature review.
Analysis of studies on transcatheter PDA closure in premature neonates.
Examination of clinical practice guidelines and expert opinions.

Main Results

Percutaneous PDA closure is established as a safe and effective procedure in selected premature infants.
The availability of transcatheter closure has shifted the decision-making process towards less invasive interventions.
Evidence supports improved outcomes and reduced complications with timely closure.

Conclusions

Transcatheter PDA closure has significantly altered the approach to managing PDA in premature neonates.
The decision-making process is now more nuanced, incorporating patient selection and procedural safety.
Continued research is essential to optimize outcomes and refine management strategies.