Evaluation of Epithelialization: Fluorescence Visualization Versus Manchester Scar Scale Versus Visual Analog Scale.

Area of Science:

• Regenerative Medicine
• Wound Healing
• Medical Imaging

Background:

• Advancements in regenerative medicine necessitate objective wound healing evaluation methods.
• Split-thickness skin graft donor sites require effective monitoring for proper healing.
• Current evaluation methods may lack objectivity and sensitivity to early changes.

Purpose of the Study:

• To investigate the utility of Illumiscan, a fluorescence visualization device, for assessing split-thickness skin graft donor site healing.
• To compare Illumiscan's performance with digital photography, the Manchester Scar Scale, and the visual analog scale.
• To establish the correlation between Illumiscan's luminance measurements and the epithelialization process.

Main Methods:

• Data collection from 16 patients' split-thickness skin graft donor sites at Tokyo Saiseikai Central Hospital.
• Utilized Illumiscan for fluorescence imaging, alongside a digital camera, Manchester Scar Scale, and visual analog scale.
• Analyzed Illumiscan images to measure luminance changes over the postoperative period.

Main Results:

• Illumiscan image luminance decreased significantly up to postoperative day 3, then stabilized, indicating early epithelialization.
• Changes in Manchester Scar Scale and visual analog scale values also correlated with epithelialization progression.
• Demonstrated a relevant correlation between fluorescence imaging and wound healing course.

Conclusions:

• Illumiscan is a potentially valuable tool for objective evaluation of split-thickness skin graft donor site healing.
• Fluorescence visualization offers a sensitive method for monitoring early epithelialization.
• Combining Illumiscan with established scales may provide comprehensive wound assessment.