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Auditory Perception

Auditory Perception

The auditory system is essential for sound perception, utilizing various critical structures. When sound waves enter the outer ear, they travel through the ear canal and cause the eardrum to vibrate. These vibrations are then transmitted to the middle ear, where three tiny bones – the malleus, incus, and stapes – amplify the sound. This amplification is crucial, as it ensures that the sound vibrations are strong enough to be conveyed to the inner ear. These vibrations then reach the...

Hearing

Hearing

When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.

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Assessment of Audio-Tactile Sensory Substitution Training in Participants with Profound Deafness Using the Event-Related Potential Technique

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Acoustically Altered Speech Perception in Frontotemporal Dementia Syndromes.

Jeremy C S Johnson^1,2, Jessica Jiang¹, Mai-Carmen Requena-Komuro^1,3

¹Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, United Kingdom.

|September 11, 2025

Summary

This summary is machine-generated.

Acoustically altered speech (AAS) perception effectively differentiates frontotemporal dementia (FTD) subtypes and predicts real-world hearing difficulties, offering a new diagnostic tool for FTD syndromes.

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Area of Science:

Neuroscience
Audiology
Neurology

Background:

Hearing impairment is a significant clinical challenge in dementia.
Acoustically altered speech (AAS) presents real-world listening difficulties, but its perception markers in frontotemporal dementias (FTDs) are not well-defined.

Purpose of the Study:

To investigate if AAS perception can differentiate between FTD syndromes.
To determine if AAS perception predicts real-world hearing symptoms in FTD patients.

Main Methods:

A cross-sectional case-control study involving 29 FTD patients (nfvPPA, svPPA, bvFTD) and 15 controls.
Participants underwent pure-tone audiometry (PTA) and three AAS tests: speech-in-babble (SIB), spectrally filtered speech (SFS), and time-compressed speech (TCS).
Real-world hearing was assessed using the modified Amsterdam Inventory for Auditory Disability and Handicap (mAIAD).

Main Results:

Patients with nonfluent/agrammatic variant primary progressive aphasia (nfvPPA) showed significantly higher PTA thresholds and worse performance on SFS and time-compressed speech (TCS) tests compared to controls and other FTD groups.
Semantic variant primary progressive aphasia (svPPA) patients also performed worse on TCS compared to controls.
Real-world hearing disability (mAIAD scores) correlated more strongly with AAS perception tests than with PTA thresholds.

Conclusions:

Acoustically altered speech (AAS) perception serves as a valuable tool to stratify different frontotemporal dementia (FTD) syndromes.
AAS perception acts as a "real-world audiogram" for assessing hearing abilities in FTD.