Anti-influenza Virus Heptaketides From a Marine-associated Fungus Aspergillus sp

Four new heptaketides (1-4), along with 11 known compounds (5-15), were isolated from the marine-associated fungus Aspergillus sp. JGT-1-3-1. The structures of the new compounds were elucidated through comprehensive analysis of nuclear magnetic resonance (one- and two-dimensional) and high-resolution electrospray ionization mass spectrometry spectroscopic data, and their absolute configurations were determined by comparing theoretical and experimental electronic circular dichroism spectra. Notably, all newly identified heptaketides exhibited significant anti-influenza A virus activity, with half-maximal inhibitory concentration values below 2 µg/mL, as assessed by the cytopathic effect assay.