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A Rat Model of Central Fatigue Using a Modified Multiple Platform Method
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Exploring factors contributing to fatigability in people with multiple sclerosis: A moderation model analysis
1Department of Physical Therapy, Faculty of Medical Rehabilitation Sciences, King Abdulaziz University, P.O. Box 80200, Jeddah, 21589, Saudi Arabia.
Acta Psychologica
|September 11, 2025
Summary
Fear of falling impacts fatigability in people with multiple sclerosis (PwMS). Addressing balance confidence and fear of falling may improve functional mobility and reduce fatigability.
Area of Science:
- Neurology
- Rehabilitation Science
- Movement Science
Background:
- Fatigability is a significant issue for people with multiple sclerosis (PwMS), impacting their daily function.
- Both perceived and performance fatigability contribute to functional decline in PwMS.
Purpose of the Study:
- To investigate factors influencing fatigability in PwMS.
- To examine the moderating effect of fear of falling on balance confidence.
Main Methods:
- 66 PwMS completed a 10-minute walk test to assess perceived and performance fatigability.
- Questionnaires included IPAQ, MFES, FSS, and ABC Scale.
- Statistical analyses involved correlation, regression, and moderation analyses.
Main Results:
- Perceived and performance fatigability correlated with falls and FSS scores, and inversely with IPAQ, MFES, and ABC scores.
- Balance confidence (ABC score) and falls predicted perceived fatigability.
- Fear of falling moderated the link between balance confidence and perceived fatigability.
Conclusions:
- Findings underscore the importance of addressing fear of falling and balance confidence in PwMS.
- Fall education strategies show potential for enhancing fatigability and functional mobility.
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