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EUROArray HPV test accuracy for cervical precancer in self- vs. clinician-collected samples using the VALHUDES
Eef van den Borst1, Davy Vanden Broeck2, Philippe De Sutter3
1Centre for the Evaluation of Vaccination (CEV), Vaccine & Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, 2650 Edegem, Belgium; Centre of Medical Genetics, Faculty of Medicine and Health Sciences, University of Antwerp and Antwerp University Hospital, 2650 Edegem, Belgium.
Human papillomavirus (HPV) testing using self-collected urine and vaginal samples shows accuracy comparable to clinician-collected samples for cervical cancer screening. This non-invasive approach offers a promising alternative for under-screened populations.
Area of Science:
- Oncology
- Virology
- Public Health
Background:
- Human papillomavirus (HPV) testing is crucial for cervical cancer screening.
- Self-collected samples (urine, vaginal) offer a non-invasive alternative to traditional cervical samples.
- Clinical performance data on self-samples is needed for widespread adoption.
Purpose of the Study:
- To evaluate the accuracy of HPV tests on self-collected urine and vaginal samples.
- To compare the performance of self-samples against clinician-collected cervical samples using the VALHUDES framework.
Main Methods:
- Five colposcopy clinics enrolled patients with abnormal cervical results.
- Patients provided first-void urine and vaginal self-samples.
- Clinician-collected cervical samples were used as a comparator.
- DNA extraction and high-risk HPV detection using the EUROArray HPV test.
- Disease outcome determined by colposcopy with or without biopsy.
Main Results:
- Data from 491 vaginal and 494 urine self-samples were analyzed.
- Relative sensitivity for CIN2+ was 0.96 for both vaginal and urine self-samples.
- Relative specificity for
Conclusions:
- The EUROArray HPV test demonstrates similar accuracy on vaginal self-samples and first-void urine compared to clinician-collected cervical samples.
- Self-sampling methods are accurate and viable for HPV testing in cervical cancer screening.
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