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Autoantibodies in long COVID: a systematic review
Fabian Wilhelm1, Janne Cadamuro2, Sylvia Mink3
1Central Medical Laboratories, Feldkirch, Austria; Department of Laboratory Medicine, Paracelsus Medical University Salzburg, Salzburg, Austria.
The Lancet. Infectious Diseases
|September 11, 2025
Summary
Autoantibodies are linked to post-COVID-19 condition (long COVID), potentially serving as biomarkers for diagnosis and prognosis. Further research is needed to confirm their clinical utility in managing long COVID.
Area of Science:
- Immunology
- Infectious Diseases
- Clinical Medicine
Background:
- Post-COVID-19 condition (long COVID) presents complex diagnostic and prognostic challenges due to varied symptoms and lack of biomarkers.
- A significant number of individuals experience profound daily life and work impacts from long COVID following SARS-CoV-2 infection.
Conclusions:
- Autoantibodies show potential as biomarkers for diagnosing, predicting prognosis, and assessing disease severity in long COVID.
- Larger studies are required to validate the diagnostic and prognostic value of these autoantibodies in the context of long COVID.
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