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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Maternal Antenatal Depression and Deviations From Normative Brain Development in Offspring.

Klara Mareckova1, Radek Marecek2, Jana Klanova3

  • 1Brain and Mind Research, Central European Institute of Technology, Masaryk University, Brno, Czech Republic; First Department of Neurology, Faculty of Medicine, Masaryk University, and St Anne's University Hospital, Brno, Czech Republic.

Biological Psychiatry. Cognitive Neuroscience and Neuroimaging
|September 11, 2025
PubMed
Summary
This summary is machine-generated.

Maternal antenatal depression (MAD) is linked to altered development of the thalamus and nucleus accumbens in offspring. These brain region differences persist into adulthood, potentially increasing depression risk.

Keywords:
Longitudinal studyMaternal antenatal depressionNormative brain developmentNucleus accumbensThalamusYoung adulthood

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Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Psychiatry

Background:

  • Maternal mental health during pregnancy is crucial for fetal brain development.
  • Prenatal exposure to maternal depression may impact offspring brain aging.
  • The long-term, region-specific effects of maternal antenatal depression (MAD) on offspring brain development are not fully understood.

Purpose of the Study:

  • To investigate whether MAD predicts region-specific deviations in cortical thickness, surface area, and subcortical volume in offspring.
  • To determine if these region-specific deviations remain stable into the third decade of life.

Main Methods:

  • Utilized neuroimaging data from a prenatal birth cohort with two follow-ups in young adulthood.
  • Employed the CentileBrain model, analyzing 37,407 MRI scans from individuals aged 3 to 90 years.
  • Assessed associations between MAD and deviations from normative brain development in offspring during their early and late 20s.

Main Results:

  • MAD predicted deviations in thalamus and nucleus accumbens development, but not other subcortical volumes, surface area, or cortical thickness.
  • Offspring exposed to greater MAD had smaller thalamus and nucleus accumbens in their early and late 20s.
  • Sex differences emerged: men exposed to greater MAD showed a larger nucleus accumbens in their late 20s, but no thalamus deviations.

Conclusions:

  • Altered development of the thalamus and nucleus accumbens, linked to MAD, may increase the risk of major depressive disorder.
  • The thalamus is implicated in depression pathogenesis, while the nucleus accumbens is vital for reward and motivation.
  • These findings highlight the lasting impact of prenatal maternal depression on specific brain structures and potential mental health outcomes.