Incidental Durotomy Significantly Increases the Risk of Postoperative Infection Following Lumbar Spine Surgery for
Tamara Babasiz1, Jannik Leyendecker2,3, Maximilian Weber2
1Faculty of Medicine and University Hospital Cologne, Department of Orthopedic and Trauma Surgery, University of Cologne, Köln, Germany Tamara.Babasiz@uk-koeln.de.
Background:
Accidental dural tear (ADT), an unintended intraoperative breach of the dura mater, is a recognized complication in lumbar spine surgery for degenerative conditions. Postoperative surgical site infections are serious adverse outcomes in this context. However, the role of ADT in increasing postoperative infection risk remains insufficiently defined. This systematic review and meta-analysis aimed to comprehensively assess the association between ADT and the occurrence of postoperative infection.
Methods:
A systematic literature search was performed in PubMed, ScienceDirect, and CENTRAL from inception to 6 August 2024. Studies involving degenerative lumbar surgery and reporting data on both incidental durotomy and postoperative infections were included. Study quality, including risk of bias analysis, was appraised by 2 independent observers. Subsequently, 2 meta-analyses were conducted, estimating the pooled incidence of infection among patients with ADT and another calculating pooled odds ratios to evaluate infection risk.
Results:
Fourteen studies comprising 376,164 patients met the inclusion criteria. The incidence of ADT ranged from 1.9% to 11.8%, with higher rates observed in revision surgeries. Key risk factors included obesity, diabetes, revision surgery, advanced age, and extended operative time. The meta-analysis comprised 7 studies, including 7500 patients with dural tears and 189,058 patients without dural tears. The pooled incidence of postoperative infection among patients with ADT was 13.1% (95% CI: 6.8%-23.8%), which was significantly higher compared with 5.4% (95% CI: 3.1%-7.5%) among patients without ADT (P = 0.00078). Substantial heterogeneity was observed across studies (I 2 = 76.5% for ADT patients and 96.0% for non-ADT patients; Tau2 = 0.63). A separate meta-analysis of 5 studies reported a pooled odds ratio of 3.86 (95% CI: 2.48-6.3, P < 0.00001), indicating a significantly increased infection risk associated with ADT.
Conclusion:
ADTs during lumbar spine surgery for degenerative conditions are associated with a significantly increased risk of postoperative infections. Although this relationship is multifactorial, affected by surgical complexity and patient comorbidities, these findings underscore the importance of heightened vigilance in infection prevention and control following ADT to reduce infection-related morbidity.
Clinical Relevance:
Incidental dural tear during lumbar spine surgery for degenerative conditions significantly increases the risk for postoperative infection and should be a focus of preventive strategies.
